Evaluation of dissolution techniques for orally disintegrating mini-tablets

Mini-tablets are suitable for paediatric as well geriatric use since they may provide flexible and accurate dosing administration. Due to the minute tablet size, there is a need new standardized quality evaluation procedures conventional techniques have be adopted. The main objective of study was evaluate different dissolution orally disintegrating mini-tablets. Dissolution tests using mini-paddle apparatus were compared with standard size paddle apparatus, effect rotation speed evaluated. Also, filter choice, its impact on dissolution, considered. Sodium salicylate used model drug substance mixed fractions mannitol. powder mixtures compacted into 2 mm flat faced tablets. mini-tablets characterized regarding weight content uniformity, tensile strength, friability, disintegration dissolution. Similar profiles obtained both mini equipment. affected profiles; low resulted in slower Furthermore, choosing chemically inert will increase likelihood obtaining reliable results. An appropriately designed test required prior further implementation control procedures.